This Phase 3, randomized, Double-blind, placebo-controlled, 2-arm, parallel-group, multicenter study with randomized withdrawal will evaluate the efficacy, safety, and durability of KBP-5074 in adult participants who have stage 3b/4 chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] calculated using the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] formula [eGFR {EPI}] ≥15 to ≤44 mL/min/1.73 m^2) and uncontrolled hypertension (systolic blood pressure (SBP) ≥140 and <180 mm Hg and taking 2 or more antihypertensive medications. [/av_textblock] [av_button label='Learn More' icon_select='no' icon='ue800' font='entypo-fontello' link='manually,https://clinicaltrials.gov/study/NCT04968184?term=KBP%20Clarion%20CKD&rank=1#study-overview' link_target='_blank' size='large' position='left' label_display='' title_attr='' size-text='' av-desktop-font-size-text='' av-medium-font-size-text='' av-small-font-size-text='' av-mini-font-size-text='' margin='' margin_sync='true' padding='' padding_sync='true' av-desktop-margin='' av-desktop-margin_sync='true' av-desktop-padding='' av-desktop-padding_sync='true' av-medium-margin='' av-medium-margin_sync='true' av-medium-padding='' av-medium-padding_sync='true' av-small-margin='' av-small-margin_sync='true' av-small-padding='' av-small-padding_sync='true' av-mini-margin='' av-mini-margin_sync='true' av-mini-padding='' av-mini-padding_sync='true' color_options='' color='theme-color' custom_bg='#444444' custom_font='#ffffff' btn_color_bg='theme-color' btn_custom_grad_direction='vertical' btn_custom_grad_1='#000000' btn_custom_grad_2='#ffffff' btn_custom_grad_3='' btn_custom_grad_opacity='0.7' btn_custom_bg='#444444' btn_color_bg_hover='theme-color-highlight' btn_custom_bg_hover='#444444' btn_color_font='theme-color' btn_custom_font='#ffffff' btn_color_font_hover='white' btn_custom_font_hover='#ffffff' border='none' border_width='' border_width_sync='true' border_color='' border_radius='' border_radius_sync='true' box_shadow='' box_shadow_style='0px,0px,0px,0px' box_shadow_color='' animation='' animation_duration='' animation_custom_bg_color='' animation_z_index_curtain='100' hover_opacity='' sonar_effect_effect='' sonar_effect_color='' sonar_effect_duration='1' sonar_effect_scale='' sonar_effect_opac='0.5' css_position='' css_position_location=',,,' css_position_z_index='' av-desktop-css_position='' av-desktop-css_position_location=',,,' av-desktop-css_position_z_index='' av-medium-css_position='' av-medium-css_position_location=',,,' av-medium-css_position_z_index='' av-small-css_position='' av-small-css_position_location=',,,' av-small-css_position_z_index='' av-mini-css_position='' av-mini-css_position_location=',,,' av-mini-css_position_z_index='' id='' custom_class='' template_class='' av_uid='av-lnj7zbrs' sc_version='1.0' admin_preview_bg='']